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Read More Especially since the fibro was discovered (about 15 years ago), my migraines have increased in frequency The mechanism of action of triptans, including sumatriptan, involves serotonin receptors (docking sites) on blood vessels in your brain. Sumatriptan nasal spray IMITREX may be taken for subsequent attacks. GlaxoSmithKline, Research Triangle Park, NC 27709 Imigran Nasal Spray20mg Spray. The imitrex nasal spray can work in 10-20 minutes. Administration during migraine aura prior to other symptoms occurring may not prevent the development of a headache. Sumatriptan nasal spray Imitrex ALSO comes in a nasal spray and an injection. Clinical trials have shown that approximately 50 -75% of patients have headache relief within twohours after oral dosing with 100 mg, and that a further 15 -25% have headache relief by 4hours IMITREX nasal spray is indicated for the acute treatment of migraine with or without aura in adults. 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