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After 100 mg is 48 approximately 25% less than expected (based on the 25-mg dose). Max: 200 mg/day ≥18yrs: 25–100mg once, swallow whole with fluids as soon as possible after migraine onset; may repeat dose at intervals of at least 2hrs, max 200mg/day; or single-dose tablets up to 100mg/day. Do not store in a refrigerator oral tablet (a tablet you swallow) 25 milligrams (mg), 50 mg, 100 mg: nasal spray: 5 mg, 20 mg: You can take your dose of Imitrex with or without food. Questions for your doctor Oral dosage Adults 25, 50, or 100 mg PO once. Sumatriptan is administered orally through hepatic first pass metabolism. You should take your dose when you first feel symptoms of migraine, but you may take a dose at. May repeat dose once after at least 2 hours after the first dose if the headache has not resolved or returns after transient improvement. 49% 46 given as a single dose, sumatriptan displays dose proportionality in its extent of absorption (area 47 under the curve [AUC]) over the dose range of 25 to 200 mg, but the C. For treating migraine, Imitrex oral tablets (pills) can be given in a dose of 25 mg, 50 mg, or 100 mg. The 20-mg dose may provide a greater effect than the 5-mg and 10-mg doses, but may have a greater risk of adverse reactions [see Clinical Studies ( 14 )]. Do not use more than 40 milligrams of Imitrex nasal spray within 24 hours. The 5-mg and 20-mg doses are given as a single spray in 1 nostril However, only 0. 49 A food effect study involving administration of IMITREX Tablets 100 mg to healthy. Oral sumatriptan in a dose of 100 mg aborts about 60% of migraine attacks within 2 h, but the headache may recur within 24 h Results: The C(max) for Zelrix was reduced to 30% and 28% of the sumatriptan s. Doses of 50 mg and 100 mg may provide a greater effect than the 25-mg dose, but doses of 100 mg may not provide a greater effect than the 50-mg dose. Questions for your doctor Dosage Forms & Strengths tablet 25mg 50mg 100mg injectable SC solution 6mg/0. Store at room temperature away from moisture, heat, and light. If some response to first dose occurs, a second dose may be administered at least 2 hours after first dose if needed; Oral doses of 50 and 100 mg may provide greater relief than 25 mg; however, a 100 mg dose may not provide greater effect than a 50 mg dose; Maximum dose: 200 mg per 24 hours. Call your doctor if your symptoms do not improve, or if you have more than 4 headaches in one month (30 days). In severe hepatic impairment, Sumavel should not be used Oral: Initial dose: 25 mg, 50 mg, or 100 mg orally, once. 5mL autoinjector (Zembrace SymTouch) 4mg/0. 7 mcg) of the 6 mg sumatriptan dose was recovered in the milk, which corresponds to a weight-adjusted mean exposure of 3. Plasma concentrations for Zelrix I and Zelrix II were intermediate between those for oral and nasal sumatriptan doses tested.. Both doses of oral sumatriptan were well tolerated. Higher doses may have a greater risk of adverse reactions [see Clinical Studies (14)] * To take a 10-mg dose of Imitrex nasal spray, you’ll use two 5-mg nasal spray devices, one in each nostril. 5mL vial (Imitrex) prefilled SC syringe/cartridge 3mg/0. Dose, thereby reducing the risk of triptan-like sensations associated with high peak plasma concentrations. Patients with hepatic impairment will need to adjust the dose in oral preparation. Dosing Information The recommended dose of IMITREX tablets is 25 mg, 50 mg, or 100 mg. No adverse events (AEs) were serious or led to study withdrawal. Do not take more than 200 milligrams of oral Imitrex within 24 hours. The recommended adult dose of Imitrex Nasal Spray for the acute treatment of migraine is 5 mg, 10 mg, or 20 mg. However, it is not necessary to adjust the dose via Non-oral routes (intranasal, intracutaneous) for patients with hepatic impairment. Assuming oral bioavailability of sumatriptan in infants is similar to adults (mean 14%), the weight-adjusted infant dose is roughly 0. Dosage for cluster headaches Only the Imitrex injection is used to treat cluster. Oral tablet (a tablet you swallow) 25 milligrams (mg), 50 mg, 100 mg: nasal spray: 5 mg, 20 mg: You can take your dose of Imitrex with or without food.

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